Autoimmune haemolytic anaemia (warm and cold)

What it is

Autoimmune hemolytic anemia is classified into two, warm and cold, and the two differ at every line. Warm accounts for 75-90% of cases and its antibody allotype is IgG. Cold carries IgM instead, and it is the one that goes with mycoplasma pneumonia and EBV. The agglutination temperature given for warm is 37°C, and for cold 4-37°C.

Causes and risk

Warm autoimmune hemolytic anemia:

Idiopathic
Secondary to a lymphoproliferative disorder, for example CLL or Hodgkin lymphoma
Secondary to autoimmune disease, for example SLE
Drug-induced, for example penicillin, quinine or methyldopa

Cold autoimmune hemolytic anemia:

Idiopathic
Secondary to infection, for example mycoplasma pneumonia or EBV
Secondary to a lymphoproliferative disorder, for example macroglobulinemia or CLL

CLL sits on both lists, so it does not separate the two.